Masashi Akaike Selected Research

Heparin Cofactor II

10/2012	Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMP-activated protein kinase-endothelial nitric-oxide synthase signaling pathway.
10/2009	Heparin cofactor II as a novel vascular protective factor against atherosclerosis.
4/2009	Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors.
6/2007	Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.
6/2004	Heparin cofactor II is a novel protective factor against carotid atherosclerosis in elderly individuals.
2/2004	High plasma heparin cofactor II activity is associated with reduced incidence of in-stent restenosis after percutaneous coronary intervention.

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Masashi Akaike Research Topics

Disease

12	Atherosclerosis 01/2018 - 09/2002
9	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 10/2009
9	Hypertension (High Blood Pressure) 11/2015 - 01/2003
8	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021 - 09/2002
7	Fibrosis (Cirrhosis) 01/2018 - 08/2005
7	Inflammation (Inflammations) 10/2017 - 10/2003
6	Heart Failure 10/2017 - 01/2008
6	Vascular Remodeling 01/2011 - 02/2004
5	Insulin Resistance 01/2021 - 01/2008
5	Acute Coronary Syndrome 03/2019 - 07/2003
5	Ischemia 01/2018 - 12/2009
5	Muscular Diseases (Myopathy) 12/2003 - 08/2002
4	Diabetes Mellitus 01/2021 - 06/2004
4	Myocardial Infarction 12/2015 - 08/2006
4	Carotid Artery Diseases 09/2010 - 06/2004
4	Mitochondrial Diseases (Mitochondrial Disease) 09/2003 - 02/2002
3	Thrombosis (Thrombus) 01/2018 - 08/2004
3	Type 2 Diabetes Mellitus (MODY) 01/2018 - 08/2015
3	Rupture 10/2017 - 09/2011
3	Body Weight (Weight, Body) 07/2016 - 02/2010
3	Essential Hypertension 01/2015 - 01/2011
3	Hypertrophy 04/2010 - 08/2005
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 12/2014 - 01/2011
2	Dyslipidemias (Dyslipidemia) 12/2014 - 01/2011
2	Cognitive Dysfunction 12/2014 - 01/2011
2	Atherosclerotic Plaque (Atheroma) 07/2014 - 09/2011
2	Ventricular Tachycardia 11/2013 - 01/2011
2	Obesity 07/2011 - 01/2011
2	Hyperlipidemias (Hyperlipidemia) 06/2011 - 01/2011
2	Systemic Scleroderma (Systemic Sclerosis) 03/2011 - 01/2010
2	Left Ventricular Dysfunction 02/2011 - 12/2009
2	Cerebral Infarction 01/2011 - 09/2002
2	Hypercholesterolemia 01/2011 - 02/2010
2	Peripheral Arterial Disease 10/2009 - 04/2009
2	Muscular Atrophy (Muscle Atrophy) 09/2003 - 08/2002
1	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2021
1	Pulmonary Embolism 01/2018

Drug/Important Bio-Agent (IBA)

8	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 03/2019 - 01/2008
6	AndrogensIBA 01/2021 - 08/2005
6	Docosahexaenoic AcidsIBA 03/2019 - 12/2014
6	Thrombin FDA Link 01/2018 - 02/2004
6	Heparin Cofactor IIIBA 10/2012 - 02/2004
6	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2011 - 08/2002
5	Eicosapentaenoic AcidIBA 03/2019 - 12/2014
4	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2008
4	pitavastatin (itavastatin)FDA Link 01/2018 - 01/2008
4	Brain Natriuretic Peptide (Natrecor)FDA Link 07/2016 - 01/2008
4	Androgen Receptors (Androgen Receptor)IBA 07/2013 - 08/2005
4	Angiotensin IIIBA 04/2010 - 08/2005
3	LipidsIBA 01/2018 - 01/2011
3	SodiumIBA 01/2018 - 07/2016
3	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2018 - 04/2010
3	Arachidonic Acid (Vitamin F)IBA 12/2015 - 12/2014
3	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 10/2015 - 06/2004
3	AlbuminsIBA 01/2015 - 02/2010
3	LDL CholesterolIBA 01/2015 - 02/2010
3	Biomarkers (Surrogate Marker)IBA 08/2014 - 10/2009
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2013 - 02/2010
3	CytokinesIBA 02/2010 - 10/2003
2	Testosterone (Sustanon)FDA Link 01/2021 - 07/2010
2	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2021 - 07/2012
2	SymportersIBA 01/2018 - 01/2017
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 10/2017 - 12/2014
2	DiureticsIBA 07/2016 - 01/2014
2	CreatinineIBA 07/2016 - 06/2011
2	Factor VII (Proconvertin)IBA 12/2015 - 02/2010
2	HDL CholesterolIBA 01/2015 - 06/2004
2	Triglycerides (Triacylglycerol)IBA 08/2014 - 06/2011
2	CholesterolIBA 07/2014 - 01/2012
2	Pharmaceutical PreparationsIBA 07/2014 - 01/2011
2	oxidized low density lipoproteinIBA 01/2014 - 02/2010
2	Proteins (Proteins, Gene)FDA Link 11/2013 - 09/2010
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2013 - 12/2009
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2013 - 12/2009
2	Collagen Type I (Type I Collagen)IBA 07/2013 - 06/2009
2	AldosteroneIBA 05/2013 - 01/2011
2	Bosentan (Tracleer)FDA Link 03/2011 - 01/2010
2	Ezetimibe (Zetia)FDA Link 01/2011 - 02/2010
2	Superoxides (Superoxide)IBA 07/2010 - 02/2002
2	Nitric Oxide Synthase (NO Synthase)IBA 04/2010 - 06/2009
2	CollagenIBA 12/2009 - 08/2005
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 06/2009 - 08/2005
2	JNK Mitogen-Activated Protein KinasesIBA 06/2009 - 10/2003
2	Transforming Growth Factor beta (TGF-beta)IBA 06/2009 - 01/2008
2	GlucocorticoidsIBA 06/2007 - 01/2003
2	Lipoprotein(a)IBA 06/2004 - 09/2002
2	Protein Isoforms (Isoforms)IBA 12/2003 - 09/2002
1	GonadotropinsIBA 01/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018
1	Warfarin (Coumadin)FDA LinkGeneric 01/2018
1	Hemoglobins (Hemoglobin)IBA 01/2018
1	Protein SIBA 01/2018
1	Antithrombin IIIIBA 01/2018
1	edoxabanIBA 01/2018
1	AnticoagulantsIBA 01/2018
1	fibrin fragment D (D-dimer)IBA 01/2018

Therapy/Procedure

12	Therapeutics 03/2019 - 09/2002
6	Stents 03/2019 - 07/2003
4	Percutaneous Coronary Intervention 12/2015 - 02/2004
3	Cardiac Rehabilitation 10/2017 - 01/2014